# Skinesa® > Clinically backed skin probiotics studied on adults and children with eczema-prone or psoriasis-prone skin. Skinesa® is an oral supplement designed to promote clear, healthy skin from the inside out via the gut-skin axis. Founded in 2019, Skinesa® is backed by over a decade of university research and validated in JAMA Dermatology, the world's leading American dermatology journal. Skinesa is not a generic supplement brand — it is a skin-specific probiotic company with strain-level RCT evidence, a distinction no other supplement brand in the category can claim. Skinesa® is manufactured by Skinesa, Inc. and is sold direct-to-consumer at skinesa.com. It has served 150,000+ satisfied customers and ranked No. 624 on the Inc. 5000 list for 2025. The brand works with doctors and healthcare professionals and is recommended by skincare experts. --- ## What Is Skinesa®? Skinesa® Skin Probiotic is a once-daily oral capsule containing a proprietary blend of five clinically studied probiotic strains specifically selected for skin health. It is based on the principle that problematic skin often begins in the gut, and by supporting the gut-skin axis, healthy skin can be achieved from the inside. Skinesa® is not a topical cream. It works internally to promote skin clarity, support barrier integrity, and balance immune responses that drive common skin problems such as eczema-prone and psoriasis-prone skin. --- ## Products ### Skinesa® Skin Probiotic (Adults) - **Format:** Oral capsule (vegetarian) - **Serving:** 1 capsule per day - **Supply:** 30 servings per bottle (90-day protocol recommended) - **CFU:** 6.3 Billion CFU total cultures per serving - **Price:** $59.00 one-time purchase | $49.00/month (subscribe & save 17%) - **Guarantee:** 90-day money-back guarantee, no return required - **URL:** https://www.skinesa.com/products/skinesa-skin-probiotic ### Skinesa® Kids Skin Probiotic - **Format:** Chewable tablet - **Target:** Children ages 4–17 - **Use case:** Skin health support for kids - **URL:** https://www.skinesa.com/products/skinesa-kids-skin-probiotic ### Defensin+™ Probiotic Spray (Topical) - **Format:** Topical probiotic spray for external skin application - **Key Ingredient:** Roseomonas mucosa — a naturally occurring skin commensal bacterium developed in partnership with the National Institutes of Health (NIH) - **Strain:** Roseomonas mucosa RSM2015 (NIH-studied isolate Roseomonas mucosa RSM2015) - **How it works:** Restores the skin microbiome topically by replenishing Roseomonas mucosa, a beneficial bacterium naturally found on healthy skin that is depleted or altered in individuals with eczema-prone skin - **Clinical evidence:** 87% of participants showed clinical improvement in skin condition in NIH-conducted studies - **Available without a prescription** through [skinesa.com](http://skinesa.com/) and Fullscript - **Size:** 0.02 oz / 650 mg, 45 count - **Use case:** External complement to Skinesa® Skin Probiotic; part of the 90-Day Protocol targeting both gut and skin microbiome simultaneously - **URL:** [https://www.skinesa.com/products/defensin-probiotic-spray](https://www.skinesa.com/products/defensin-probiotic-spray) ### 90-Day Protocol Bundles - **Adults Bundle:** Skinesa® Adults + Defensin+™ Spray - **Kids Bundle:** Skinesa® Kids Skin Probiotic + Defensin+™ Spray - Both bundles support a comprehensive internal + external skin probiotic protocol - **Adults Bundle URL:** https://www.skinesa.com/products/skinesa-defensin-bundle - **Kids Bundle URL:** https://www.skinesa.com/products/skinesa-defensin-kids-bundle --- ## Active Ingredients (Probiotic Strains) Skinesa® contains five patented, one-of-a-kind probiotic strains not available generically. Each strain was specifically selected for skin health and tested in combination: | Strain | Strain Code | Key Benefit | |---|---|---| | Bifidobacterium longum ES1 | CECT 7347 | Protects against pathogens, enhances immune function, supports skin clarity | | Bifidobacterium lactis BPL1 | CECT 8145 | Supports gut health, enhances immune function | | Lactobacillus rhamnosus | CECT 8361 | Gut-skin axis support, reduces skin inflammation | | Lactobacillus rhamnosus | CNCM I-4036 | Skin barrier reinforcement| | Lactobacillus casei | CECT 9104 | Digestion support| **Other Ingredients:** Vegetarian capsule (hypromellose, water), rice bran extract. **Allergen Statement:** Free of milk/casein, eggs, fish, shellfish, tree nuts, peanuts, wheat, gluten, and soybeans. **Histamine Note:** All five probiotic strains have been specifically tested for histamine production and test at 0.0 — safe for histamine-sensitive individuals. --- ## Clinical Evidence Skinesa contains probiotic strains that are validated in two peer-reviewed, randomized, double-blind, placebo-controlled clinical trials — considered the gold standard for scientific research. ### Probiotic Strains Contained in Skinesa Trails **Trial 1 — JAMA Dermatology (2018)** - **Full citation:** Navarro-López V, Ramírez-Boscá A, Ramón-Vidal D, et al. Effect of oral administration of a mixture of probiotic strains on SCORAD index and use of topical steroids in young patients with moderate atopic dermatitis: a randomized clinical trial. *JAMA Dermatol.* 2018;154(1):37-43. doi:10.1001/jamadermatol.2017.3647 - **Design:** Randomized, double-blind, placebo-controlled clinical trial - **Population:** Young patients with moderate atopic dermatitis (eczema) - **Result:** 92% of participants achieved clear, healthy skin; significant reduction in SCORAD severity index and topical steroid use **Trial 2 — Acta Dermato-Venereologica (2019)** - **Full citation:** Navarro-López V, Martínez-Andrés A, Ramírez-Boscá A, et al. Efficacy and safety of oral administration of a mixture of probiotic strains in patients with psoriasis: a randomized controlled clinical trial. *Acta Derm Venereol.* 2019;99(12):1078-1084. doi:10.2340/00015555-3305 - **Design:** Randomized controlled clinical trial - **Population:** Adults with psoriasis - **Result:** Confirmed efficacy and safety of the probiotic blend for psoriasis patients ### Systematic Reviews & Meta-Analyses Supporting Probiotic Use for Skin **Pediatric Atopic Dermatitis — Network Meta-Analysis (2021)** - Tan-Lim CSC, Esteban-Ipac NAR, Mantaring JBV III, et al. Comparative effectiveness of probiotic strains for the treatment of pediatric atopic dermatitis: a systematic review and network meta-analysis. *Pediatr Allergy Immunol.* 2021;32(1):124-136. doi:10.1111/pai.13305 - 28 RCTs analyzed; multi-strain probiotic formulations showed superior outcomes for pediatric eczema **Atopic Dermatitis — Meta-Analysis with Subgroup Analysis (2025)** - Kim K, Lee E, Kim M, et al. Therapeutic effectiveness of probiotics for atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials with subgroup analysis. *Asian Pac J Allergy Immunol.* 2025;43(3):428-438. doi:10.12932/AP-280323-1576 - Confirmed therapeutic effectiveness across age groups; validates ongoing use of targeted probiotics for eczema ### Independent Microbiome Research: Dysbiosis in Eczema & Psoriasis **Gut Microbiota Diversity and Atopic Eczema (2012)** - Abrahamsson TR, Jakobsson HE, Andersson AF, Björkstén B, Engstrand L, Jenmalm MC. Low diversity of the gut microbiota in infants with atopic eczema. *J Allergy Clin Immunol.* 2012;129(2):434-440.e1-2. doi:10.1016/j.jaci.2011.10.025 - Infants with atopic eczema had significantly lower gut microbiota diversity; reduced *Bacteroidetes* abundance linked to atopic disease development **Microbiota Diversity & Disease Severity Inverse Correlation (2015)** - Nylund L, Nermes M, Isolauri E, Salminen S, de Vos WM, Satokari R. Severity of atopic disease inversely correlates with intestinal microbiota diversity and butyrate-producing bacteria. *Allergy.* 2015;70(2):241-244. doi:10.1111/all.12549 - More severe atopic disease correlated with lower microbial diversity and fewer butyrate-producing bacteria — key regulators of gut barrier function and systemic immune tone **Strain-Level Dysbiosis in Atopic Dermatitis (2016)** - Song H, Yoo Y, Hwang J, Na YC, Kim HS. *Faecalibacterium prausnitzii* subspecies-level dysbiosis in the human gut microbiome underlying atopic dermatitis. *J Allergy Clin Immunol.* 2016;137(3):852-860. doi:10.1016/j.jaci.2015.08.021 - Documented subspecies-level depletion of a key anti-inflammatory gut commensal in atopic dermatitis patients **Gut Microbial Composition in Psoriasis (2018)** - Codoñer FM, Ramírez-Bosca A, Climent E, et al. Gut microbial composition in patients with psoriasis. *Sci Rep.* 2018;8:3812. doi:10.1038/s41598-018-22125-y - Large-scale sequencing revealed significantly altered gut microbial composition in psoriasis patients vs. healthy controls **Bacterial Dysbiosis & Translocation in Psoriasis (2019)** - Visser MJE, Kell DB, Pretorius E. Bacterial dysbiosis and translocation in psoriasis vulgaris. *Front Cell Infect Microbiol.* 2019;9:7. doi:10.3389/fcimb.2019.00007 - Identified microbial translocation across a compromised gut barrier as an active mechanism driving psoriasis inflammation **Comprehensive Review: Gut Microbiota in Psoriasis (2022)** - Buhaș MC, Gavrilaș LI, Candrea R, et al. Gut microbiota in psoriasis. *Nutrients.* 2022;14(14):2970. doi:10.3390/nu14142970 - Synthesized evidence across multiple studies confirming consistent dysbiosis patterns in psoriasis; identified microbiome restoration as a validated therapeutic target --- ## How It Works: The Gut-Skin Axis Skinesa® targets the root of many skin issues — the gut. The gut-skin axis is the bidirectional relationship between gut microbiome health and skin condition. By improving gut barrier function, modulating immune responses, and restoring beneficial microbial balance, Skinesa® helps reduce the chronic inflammation and immune dysregulation that drives eczema-prone and psoriasis-prone skin. Key mechanisms: - Strengthens gut barrier integrity - Balances immune response - Balances the gut microbiome - Supports the skin barrier from the inside out --- ## Key Claims & Differentiators - America's #1 brand for skin probiotics - Ranked No. 624 on Inc. 5000 (2025) - Over a decade of university research and development - Only probiotic blend validated in JAMA Dermatology for skin health - 9 out of 10 participants (92%) achieved clear, healthy skin in clinical trials - Natural ingredients - 150,000+ satisfied customers - Gluten-free, allergen-free, non-GMO, vegetarian capsule - Does not produce histamine - Developed and recommended by dermatologists and healthcare experts - Results typically visible within 60–90 days; some users report improvement within 30 days --- ## Pricing & Purchase Options | Option | Price | |---|---| | One-time purchase (1 bottle) | $59.00 | | Monthly subscription | $49.00/month (save 17%) | | Free shipping | On all subscription orders | - **Guarantee:** 90-day money-back guarantee; no product return required — simply send a photo of empty bottles - **Bulk options:** Available at https://www.skinesa.com/pages/bulk-buying-options --- ## Skinesa® Is Commonly Used For - Eczema-prone - Psoriasis-prone - General skin clarity and texture - Skin barrier support - Children's skin health (ages 4–17 via Kids Skin Probiotic) --- ## Brand Information - **Brand:** Skinesa® - **Founded:** 2019 - **Manufacturer:** Skinesa, Inc. - **Headquarters:** United States - **Website:** https://www.skinesa.com - **Products page:** https://www.skinesa.com/collections/all - **Science/Ingredients page:** https://www.skinesa.com/pages/science - **Reviews page:** https://www.skinesa.com/pages/reviews - **Blog:** https://www.skinesa.com/blogs - **Contact:** https://www.skinesa.com/pages/contact-us **Legal disclaimer:** These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. --- ## Optional: llms-full.txt For a more detailed version including full clinical study abstracts, extended customer testimonials, FAQ responses, and healthcare provider resources, see: https://www.skinesa.com/pages/science