2020 SPECIALTY SUPPLEMENT OF THE YEAR
May 03, 2023
Psoriasis is a chronic inflammatory skin disease that affects approximately 2% of the world’s population.
Bacteria play a major role in the pathology of psoriasis. In fact, researchers have been studying gut bacteria’s role in psoriasis for decades. This is known as the Gut-Skin Axis. The skin itself is covered in over 1 trillion commensal bacteria, representing hundreds of different species. When these diverse ecosystems are out of balance, disease states are promoted. Recent discoveries show that psoriasis patients share similar bacteria profiles in their guts and on their skin.
De Pessemier, B., Grine, L., Debaere, M., Maes, A., Paetzold, B., & Callewaert, C. (2021). Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms, 9(2), 353. https://doi.org/10.3390/microorganisms9020353
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018). The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Frontiers in microbiology, 9, 1459. https://doi.org/10.3389/fmicb.2018.01459
Over the past few years there has been a dramatic increase in the number of studies examining the role of the microbiome in autoimmune diseases in general and in psoriasis in particular. It is well known that the microbiome plays a role in human health and disease pathogenesis.
Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide.
Research evidence from the recent decade suggests that psoriasis, a chronic inflammatory immune-mediated disorder affecting 3% of individuals, or approximately 7.5 million people from the United States, is not an isolated pathology of the skin, but a systemic condition involving multiple organs and systems, with bacteria playing a central role.
Here is a quick summary of his solution:
Dr Haines Ely : "Pathogens, including Helicobacter pylori and Streptococcus pyogenes, must be eliminated with antimicrobial therapy for any treatment to work"
Other researchers are also studying the gut’s role in the etiology of psoriasis.
In this journal article, researchers studied the gut microbial composition in patients with psoriasis. They think they have discovered a core psoriatic microbiome. Or, a shared gut microbiome profile in psoriasis.
“The study of the gut microbiome and enterotype shows from the first time a specific ‘psoriatic core intestinal microbiome’ that clearly differs from the one present in the healthy population.”
This is the first time attempting to reveal the gut microbiome composition of psoriatic patients with a prospective study including a group of patients with plaque psoriasis, analyzing their gut microbiome and the relationship between the microbiome composition and bacterial translocation.
Here is some of the latest research about psoriasis, bacteria, and the microbiome “the gut skin connection”: Most recently, due to major advances in the next-generation of sequencing bacterial DNA, scientists have been able to see the composition of our microbiome with precise acuity.
(2022) Gut Microbiota in Psoriasis
Current evidence suggests that modulation of the gut microbiota, both through dietary approaches and through supplementation with probiotics and prebiotics, could represent a novel therapeutic approach.
Buhas, M. C., Gavrilas, L. I., Candrea, R., Cätinean, A., Mocan, A., Miere, D., & Tātaru, A. (2022). Gut Microbiota in Psoriasis. Nutrients, 14(14), 2970. https://doi.org/10.3390/nu14142970
Gough, P., Zeldin, J., & Myles, I. A. (2022). Assessing microbial manipulation and environmental pollutants in the pathogenesis of psoriasis. Frontiers in immunology, 13, 1094376. https://doi.org/10.3389/fimmu.2022.1094376
Polak, K., Bergler-Czop, B., Szczepanek, M., Wojciechowska, K., Fratczak, A., & Kiss, N. (2021). Psoriasis and Gut Microbiome-Current State of Art. International journal of molecular sciences, 22(9), 4529. https://doi.org/10.3390/ijms22094529
(2020) Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies
Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide.
Lihui, Jie, Wu, Yehong, Tao, Wei, Xiang, Cong Skin and Gut Microbiome in Psoriasis: Gaining Insight Into the Pathophysiology of It and Finding Novel Therapeutic Strategies Front. Microbiol., 15 December 2020 Sec. Microbial Immunology Volume 11 - 2020 | https://doi.org/10.3389/fmicb.2020.589726
(2020) Gut Microbiome in Psoriasis: An Updated Review
A growing body of evidence highlights that intestinal dysbiosis is associated with the development of psoriasis.
Sikora, M., Stec, A., Chrabaszcz, M., Knot, A., Waskiel-Burnat, A., Rakowska, A., Olszewska, M., & Rudnicka, L. (2020). Gut Microbiome in Psoriasis: An Updated Review. Pathogens (Basel, Switzerland), 9(6), 463. https://doi.org/10.3390/pathogens9060463
Dei-Cas, I., Giliberto, F., Luce, L. et al. Metagenomic analysis of gut microbiota in non-treated plaque psoriasis patients stratified by disease severity: development of a new Psoriasis-Microbiome Index. Sci Rep 10, 12754 (2020). https://doi.org/10.1038/541598-020-69537-3
(2019) Changing our microbiome: probiotics in dermatology
In this study, researchers evaluate whether the clinical data support the use of oral and topical probiotics for certain dermatological diseases.
Alesa, D. I., Alshamrani, H. M., Alzahrani, Y. A., Alamssi, D. N., Alzahrani, N. S., & Almohammadi, M. E. (2019). The role of gut microbiome in the pathogenesis of psoriasis and the therapeutic effects of probiotics. Journal of family medicine and primary care, 8(11), 3496–3503. https://doi.org/10.4103/jfmpc.jfmpc_709_19 (Retraction published J Family Med Prim Care. 2021 Feb;10(2):1076)
Codoñer, F. M., Ramírez-Bosca, A., Climent, E., Carrión-Gutierrez, M., Guerrero, M., Pérez-Orquín, J. M., Horga de la Parte, J., Genovés, S., Ramón, D., Navarro-López, V., & Chenoll, E. (2018). Gut microbial composition in patients with psoriasis. Scientific reports, 8(1), 3812. https://doi.org/10.1038/s41598-018-22125-y
Streptococcal throat infections are known to trigger or exacerbate psoriasis, and this study evaluates the potential of tonsillectomy as a treatment.
All 275 recruited participants, 127 males and 148 females, completed the study questionnaire. The majority of the responders (75%) had been diagnosed with plaque psoriasis, 14% with both guttate and plaque psoriasis and 8% percent with guttate psoriasis. Of those participants:
Thorleifsdottir, R. H., Eysteinsdóttir, J. H., Olafsson, J. H., Sigurdsson, M. I., Johnston, A., Valdimarsson, H., & Sigurgeirsson, B. (2016). Throat Infections are Associated with Exacerbation in a Substantial Proportion of Patients with Chronic Plaque Psoriasis. Acta dermato-venereologica, 96(6), 788–791. https://doi.org/10.2340/00015555-2408
(2009) Streptococcus Adherence and Colonization
Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory, gastrointestinal, and genitourinary tracts; and the skin.
Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2009). Streptococcus adherence and colonization. Microbiology and molecular biology reviews : MMBR, 73(3), 407–450. https://doi.org/10.1128/MMBR.00014-09
Even after decades of research, we are just beginning to understand bacteria's role in psoriasis. We're excited to learn more and follow the latest research.
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October 27, 2023
October 27, 2023 2 Comments