Improves the look and feel of your skin in 90 days or less.
A skin health breakthrough from over 7 years of research, Defensin+™ Probiotic Spray was created by a team of experts to promote healthy skin.
Probiotic strain Roseomonas mucosa RSM 2015 clinically shown to improve skin health.(1),(2)
9 out of 10 participants achieved clearer, healthier skin in the clinical trial.(1)
Innovated and studied by experts at the NIH.(1),(2)
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Probiotic innovated and tested against placebo by NIH research.(1,2)
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Participants saw reduction of itchy, dry, inflamed skin.
Participants achieved clear, healthy skin.
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
(1) Myles, Ian A et al. Sci Transl Med 2020 Sep 9;12(560):eaaz8631. doi: 10.1126/scitranslmed.aaz8631.
(2) Myles, Ian A, et al. JCI Insight. 2018 May 3;3(9):e120608. doi: 10.1172/jci.insight.120608.
Defensin+™ contains a topical probiotic discovered and tested by a team of experts to soothe itchy, rashy skin. Probiotics are live microorganisms that provide a health benefit when administered in specific amounts.
Our probiotic strain Roseomonas RSM2015 has been shown to be a ceramide producer. Ceramides are important for retaining your skin's moisture and strengthening skin barrier function. Our live probiotic has been proven safe and effective in placebo controlled clinical trials. Academic research has demonstrated that Roseomonas mucosa RSM2015 is the top probiotic strain for protecting and enhancing the skin barrier. In addition, ground cardamom seed soothes itchy skin caused by the overactivation of TRPA1.
Roseomonas mucosa RSM2015, ground cardamom seeds, and sucrose
Probiotics are live microorganisms that provide health benefits when administered in adequate amounts. By definition, probiotics must have a scientifically demonstrated health effect.
In the case of Defensin+™ Topical Skin Probiotic, our probiotic ingredient can be matched to two randomized controlled clinical trials that show safety and efficacy in promoting clear, healthy skin. Our probiotic is a one-of-a-kind probiotic strain that is not available generically.
Note: 99% of the "probiotic" topical skincare products are not probiotics at all, rather they are lysates, or probiotic byproducts which are not living.
Buy with confidence - if you're unsatisfied for any reason, return within 90 days, no questions asked, just email us at support@skinesa.com for easy to follow instructions. We offer a 100% hassle-free refund guarantee. Our refund policy here.
We recommended spraying the probiotic ingredients onto the desired areas where you would like healthier skin. For optimal and sustained results, we suggest continuous, every other day use for at least 90 days.
Clinical evidence shows that Roseomonas mucosa RSM2015 promotes healthier skin.
You may see results within a few days, but clinical evidence from clinics shows that you will get the best benefits for your skin following 90 days of every other day of use.
Use warm water to flush it out. If you think your spray bottle has a clog, we suggest taking the top off and placing the tubing (with the nozzle still attached) in a cup of warm water; pump the spray top until water sprays out with ease. Once you're satisfied with the mechanism, place the top back onto the bottle and continue using.
Yes. We suggest using cooled distilled water as the safest option out of an abundance of caution. Filtered, clean water is another option.
No. You should clean out your bottle after every use. We suggest the maximum you should leave the probiotics in water to remain effective is less than 30 minutes.
Yes. However, do not spray in or near the eyes.
We advise consulting with your physician if you are currently taking medications.
There are no known side effects based on the 2 successful clinical trials.
First thing in the morning before your morning routine and/or right before you go to bed at night. Allowing yourself a little time to air dry is ideal.
For best results, we suggest applying lotions at a different part of the day. For example, if you apply Defensin+™ at night, apply lotions in the morning. In addition, please be aware that some popular lotions have been shown to kill R. Mucosa RSM2015. Please read more here.
You should receive instant results from itching during the first applications. (This is from the ground cardamom seeds) However, you should experience healthier, clear skin after a few weeks of probiotic application. The best and longest lasting results in clinical trials were achieved after 90 days of every other day application.
I developed dyshidrotic eczema on my hand about 5 years ago. I've tried everything. Steroids made it worse. My hand would crack open and bleed and wouldn't heal, it was awful. I used this spray for 3 months and it's been 6 weeks since I finished the course and I am still flair free!! My skin has finally healed!
First and foremost, this product worked great for me! I had a reoccurrence of eczema about two years ago after having it under control for five years and could not quite get it back under control. I ordered this product not expecting it to work, but I noticed a marked improvement within a week. My issue is the delivery. You get a mini spray bottle with the product, but like another reviewer, it stopped working after the first use. No biggie - I make most of my cleaning and skin care products so I have nice spray bottles on hand. I used one of my own and same thing - sprayer got clogged after one use. I’m assuming there’s something about the product that gets too sticky in the sprayer that it gets clogged so I ordered a one-time use pack of glass mini spray bottles from Amazon (not economical or sustainable but it was working and I’m desperate) so I use a new spray bottle to apply the product every other day. Sometimes I can’t even get the entire product out before the bottle clogs. It’s sooo frustrating! Still giving 5 stars because it works amazingly well, but there’s got to be another way to apply this product!? I’m going to try to mix it and add to a cotton ball to apply…at this point, I’m running out of spray bottles and don’t know what else to do to apply the product.
I’ve struggled with seb derm for 13 years (I’ve tried everything but shots—steroids, creams, herbs) and this is the first time I’ve experienced any relief. It’s not perfect, but it’s so much better and less embarrassing. My scalp is mostly clear and my ears are way less dry. I still have a couple small patches on my scalp and behind my ears but compared to this time last year, there has been a real change. I think I’ve missed one day in about 90 days.
We have a young daughter with eczema and we aren't using steroids but only natural products. This product could have worked possibly if she was older and could tolerate the dryness/itchiness better, like adults or young adults can (mental preparation and self control) but she's too young for that. The product calls to use it when no other moisturizer is being used but her skin needed moisturizer or she goes out of control. Again, she's very young and cannot control her want to itch yet. May try again at a later date. Customer support and refund was amazing, I really appreciate their standing behind the product
It was helpful. It Delivered fast. I need to order more.
Thank you.
My baby girl broke out all over her body with various eczema spots. We did an elimination diet and learned she’s sensitive to gluten so we cut that out. Once we did the eczema stopped spreading but it wouldn’t heal. We added this topical spray to our regimen and it reversed it by 98% in two months. Were very pleased with it. I just wish we could apply it every day so it’s an easier regimen to remember!
I bought this for my teenage daughter who has had eczema since an infant. She has been using the spray along with the pill for 3 months. She has not had any eczema breakouts since starting and the discoloration of her skin seems to be evenly my out. The only negative I would say is then spray bottle clogs very easily. I contacted customer service and the sent my 2 new bottles but those clogged within a few uses. I cleaned them after each use per the instructions. Luckily I had my own bottle and that has need working fine. So, it is an issue with the Defensin bottle. We had tried everything even prescription from Dermatologists and nothing has worked like Skinesa line.
I’m about halfway through the box, and I’m seeing a difference! I have rosacea and dermatitis. My skin is sensitive to nearly every skincare product (I break out little sores). So, I’m super relieved that my skin is tolerating the spray. We’re not 100% yet, but there’s significantly less redness now! I’ve tried A LOT of products, and this is one of the most helpful I’ve tried.
This (and Skinesa) helped heal my eczema that was on my hands. I have tried EVERYTHING, and this was a last ditch effort. I cried when I realized my hands were healing!
I even bought more so my daughter could try it out, and her eczema is clearing up, too!
I was disappointed that it did not work for me, but the customer service was great and they immediately refunded my money with no questions asked. I still recommend for others to try it as it may help you.
We encapsulate probiotics proven safe and effective for promoting skin health in double-blind, placebo-controlled controlled clinical trials.
About the Clinical Trials
University-based, double-blind, placebo-controlled trial measured the effects of our probiotic mixtures in skin health
Peer Reviewed & Published
After passing a rigorous review, our gold standard clinical study was published in JAMA Dermatology — a top-tier, internationally recognized, peer-reviewed American medical journal.
A second study was published in ACTA Dermatology - a prominent European medical journal:
Why It Matters
We are incredibly proud of the evidence-based products we formulate, and we believe clinical studies are the best way to directly measure their impact.
