$193.95
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Dual-Action Probiotic Care: The first bundle to address skin health at every level. Defensin+ restores balance directly on the skin, while Skinesa® strengthens the foundation from the gut-together providing comprehensive, evidence-based support.
Skinesa® Kids is a daily probiotic chewable that supports better skin health in children by restoring balance where it begins: in the gut. Backed by peer-reviewed research and formulated by experts.
Our ingredients contain the 1st probiotic blend for skin health published in JAMA
Dermatology. (Published by the American Medical Association).
University research shows that problematic skin starts in the gut. To address specific imbalances specific to those with skin problems, our experts formulated a probiotic blend to promote healthy skin through the gut skin axis. Their aim was to balance the gut microbiome, protect the gut wall, balance the immune response, and enhance the skin barrier.
The ingredients in Skinesa® Kids have been studied in clinical trials and the
results were clear:
92% of children saw visibly healthier skin in 90 days or less.
This isn’t just another probiotic. It’s a targeted, science-backed formula for families looking for real answers. Our ingredients are patented, one-of-a-kind
probiotic strains not available generically.
Most start to see some progress within the first few weeks, especially with consistent use. The best results are achieved with 90 days of continual use.
In the breakthrough clinical trial, the results took longer than 30 days to achieve substantial results. Here is the percentage of children who achieved clear or almost clear skin versus the number of days.
That’s why we recommend completing the full 90-day protocol before evaluating results.
The ingredients in Skinesa® have been tested in a randomized controlled clinical trial in ages 4-17 that was published in JAMA Dermatology. (A top-tier, peer-reviewed medical journal published by The American Medical Association). If you are considering supplementing for a child ages 4-17, please consult with your pediatrician. It's best to ask your pediatrician if you are considering using any dietary supplement.
Most probiotics aren’t made for skin — and almost none are clinically tested in children.
It contains five patented probiotic strains, each carefully selected for their role in supporting healthy skin — not just the gut. Our probiotic ingredients were studied in gold-standard clinical trials on children ages 4–17.
The results? Up to 92% saw visibly healthier skin in less than 90 days.
Skinesa® Kids is designed for children ages 4 and up. Our probiotic ingredients were studied in gold-standard clinical trials on children ages 4–17. We recommend consulting with your pediatrician before starting any dietary supplement.
Absolutely. One berry-flavored chewable a day — no powders, no mess, and no swallowing pills.
Skinesa® stands behind our 90-Day Money Back Guarantee. Feel free to get a full refund for any reason within 90 days of purchase without having to return the product. All we kindly ask is that you send us a photo of your empty bottles with your refund request so we can avoid fraud.
Orders ship in 1–2 business days from our U.S. facility. Most orders arrive in 3–5 days, and you’ll get tracking info as soon as it leaves our facility.
We offer a 90-Day 90-Day Money Back Guarantee. If you’re not satisfied within 90 days from purchase, simply reach out — no returns, no hassle. All we kindly ask is that you send us a photo of your empty bottles with your refund request so we can avoid fraud.
There are no known side effects based on the 2 successful randomized controlled clinical trials.
We recommend consulting with your pediatrician before starting any dietary supplement. It is a good idea to specifically reference our clinical trial published in JAMA Dermatology. (Published by the American Medical Association).
Copy and paste our reference into PubMed or any internet browser:
doi:10.1001/jamadermatol.2017.3647
Skinesa®’s next generation probiotic ingredients can be matched to 2 randomized controlled clinical trials that show safety and efficacy in promoting clear, healthy skin. Our ingredients have been tested against placebo and published in peer reviewed medical journals.
Here are our ingredients:
Bifidobacterium longum CECT 7347
Bifidobacterium lactis CECT 8145
Lactobacillus rhamnosus CECT 8361
Lactobacillus casei CECT 9104
Lactobacillus rhamnosus CNCM I-4036
Here are our references:
Study #1: https://pubmed.ncbi.nlm.nih.gov/29117309/
Study #2: https://pubmed.ncbi.nlm.nih.gov/31453631/
Our ingredients are patented, one-of-a-kind probiotic strains not available generically.
Please visit our Ingredients Page for detailed information.
Skinesa®’s next generation probiotic ingredients can be matched to 2 randomized controlled clinical trials that show safety and efficacy in promoting clear, healthy skin. Our ingredients have been tested against placebo and published in peer reviewed medical journals.
Here are our ingredients:
Bifidobacterium longum CECT 7347
Bifidobacterium lactis CECT 8145
Lactobacillus rhamnosus CECT 8361
Lactobacillus casei CECT 9104
Lactobacillus rhamnosus CNCM I-4036
Here are our references:
Study #1: https://pubmed.ncbi.nlm.nih.gov/29117309/
Study #2: https://pubmed.ncbi.nlm.nih.gov/31453631/
Our ingredients are patented, one-of-a-kind probiotic strains not available generically.
Please visit our Ingredients Page for detailed information.
Skinesa uses a Kosher-certified Stevia extract extracted from NON-GMO (Non-Genetically Modified Organism) for our sweetener and contains no artificial colors or preservatives.
There are no known allergens in our formulation. We are FREE of the Top 9 Allergens: Skinesa® Kids contains NO MILK, NO EGGS, NO FISH, NO SHELLFISH, NO TREE NUTS, NO PEANUTS, NO WHEAT, NO SOYBEANS, AND NO SESAME.
There are no known allergens in our formulation. We are FREE of the Top 9 Allergens: Skinesa® Kids contains NO MILK, NO EGGS, NO FISH, NO SHELLFISH, NO TREE NUTS, NO PEANUTS, NO WHEAT, NO SOYBEANS, AND NO SESAME.
Most start to see some progress within the first few weeks, especially with consistent use. The best results are achieved with 90 days of continual use.
In the breakthrough clinical trial, the results took longer than 30 days to achieve substantial results. Here is the percentage of children who achieved “clear or almost clear skin” versus the number of days.
That’s why we recommend completing the full 90-day protocol before
evaluating results.
Yes. Skinesa®’s next generation probiotic ingredients can be matched to a randomized controlled clinical trial that showed safety and efficacy in promoting clear, healthy skin in ages 4-17.
Our ingredients have been tested against placebo and published in peer reviewed medical journals.
Here are our ingredients:
Bifidobacterium longum CECT 7347
Bifidobacterium lactis CECT 8145
Lactobacillus rhamnosus CECT 8361
Lactobacillus casei CECT 9104
Lactobacillus rhamnosus CNCM I-4036
Here are our references:
Study #1: https://pubmed.ncbi.nlm.nih.gov/29117309/
Study #2: https://pubmed.ncbi.nlm.nih.gov/31453631/
Our ingredients are patented, one-of-a-kind probiotic strains not available generically.
Please visit our Ingredients Page for detailed information.
The unique probiotic strains in Skinesa® DO NOT produce histamine. Histamine production in probiotics is tested at the probiotic strain level. To clarify, a probiotic strain can be identified by referencing the numbers and letters after the species name.
Each and every one of our probiotic strains has been specifically tested by experts for histamine production and the results tested to 0.0.
For example, L. casei is a probiotic species that comes up often in regards to histamine production. In Skinesa® Skin Probiotic, our ingredient L. casei CECT 9104 is a probiotic strain that was specifically tested for histamine production, and it does not produce histamine.
There are no known side effects based on the 2 successful randomized controlled clinical trials.
If you experience any sort of discomfort or perceived issue, we recommend that you immediately discontinue use and consult with your pediatrician. It is a good idea to specifically reference our clinical trial published in JAMA Dermatology.
(Published by the American Medical Association)
We recommend consulting with your pediatrician before starting any dietary supplement. It is a good idea to specifically reference our clinical trial published in JAMA Dermatology. (Published by the American Medical Association)
Copy and paste our reference into PubMed or any internet browser, or click here:
doi:10.1001/jamadermatol.2017.3647
Probiotics are considered transient, so they pass through the system and do not
colonize. You get the benefits while you are supplementing.
Please note: We do not have evidence that taking more daily will generate faster results as it has not been studied.
Defensin+™ contains a topical probiotic discovered and tested by a team of experts to soothe itchy, rashy skin. Probiotics are live microorganisms that provide a health benefit when administered in specific amounts.
Our probiotic strain Roseomonas RSM2015 has been shown to be a ceramide producer. Ceramides are important for retaining your skin's moisture and strengthening skin barrier function. Our live probiotic has been proven safe and effective in placebo controlled clinical trials. Academic research has demonstrated that Roseomonas mucosa RSM2015 is the top probiotic strain for protecting and enhancing the skin barrier. In addition, ground cardamom seed soothes itchy skin caused by the overactivation of TRPA1.
Roseomonas mucosa RSM2015, ground cardamom seeds, and sucrose
Probiotics are live microorganisms that provide health benefits when administered in adequate amounts. By definition, probiotics must have a scientifically demonstrated health effect.
In the case of Defensin+™ Topical Skin Probiotic, our probiotic ingredient can be matched to two randomized controlled clinical trials that show safety and efficacy in promoting clear, healthy skin. Our probiotic is a one-of-a-kind probiotic strain that is not available generically.
Note: 99% of the "probiotic" topical skincare products are not probiotics at all, rather they are lysates, or probiotic byproducts which are not living.
Buy with confidence - if you're unsatisfied for any reason, return within 90 days, no questions asked, just email us at support@skinesa.com for easy to follow instructions. We offer a 100% hassle-free refund guarantee. Our refund policy here.
We recommended spraying the probiotic ingredients onto the desired areas where you would like healthier skin. For optimal and sustained results, we suggest continuous, every other day use for at least 90 days.
Clinical evidence shows that Roseomonas mucosa RSM2015 promotes healthier skin.
You may see results within a few days, but clinical evidence from clinics shows that you will get the best benefits for your skin following 90 days of every other day of use.
Use warm water to flush it out. If you think your spray bottle has a clog, we suggest taking the top off and placing the tubing (with the nozzle still attached) in a cup of warm water; pump the spray top until water sprays out with ease. Once you're satisfied with the mechanism, place the top back onto the bottle and continue using.
Yes. We suggest using cooled distilled water as the safest option out of an abundance of caution. Filtered, clean water is another option.
No. You should clean out your bottle after every use. We suggest the maximum you should leave the probiotics in water to remain effective is less than 30 minutes.
Yes. However, do not spray in or near the eyes.
We advise consulting with your physician if you are currently taking medications.
There are no known side effects based on the 2 successful clinical trials.
First thing in the morning before your morning routine and/or right before you go to bed at night. Allowing yourself a little time to air dry is ideal.
For best results, we suggest applying lotions at a different part of the day. For example, if you apply Defensin+™ at night, apply lotions in the morning. In addition, please be aware that some popular lotions have been shown to kill R. Mucosa RSM2015. Please read more here.
You should receive instant results from itching during the first applications. (This is from the ground cardamom seeds) However, you should experience healthier, clear skin after a few weeks of probiotic application. The best and longest lasting results in clinical trials were achieved after 90 days of every other day application.
We encapsulate probiotics proven safe and effective for promoting skin health in double-blind, placebo-controlled controlled clinical trials.
About the Clinical Trials
University-based, double-blind, placebo-controlled trial measured the effects of our probiotic mixtures in skin health
Peer Reviewed & Published
After passing a rigorous review, our gold standard clinical study was published in JAMA Dermatology — a top-tier, internationally recognized, peer-reviewed American medical journal.
A second study was published in ACTA Dermatology - a prominent European medical journal:
Why It Matters
We are incredibly proud of the evidence-based products we formulate, and we believe clinical studies are the best way to directly measure their impact.
